Sanchez has been working his way back from injury.
Pochettino said before kickoff: "We always need to provide the team the best to perform. Enzo is suspended, Rob coming back from injury little by little is good for the team. We are going to be very offensive, four offensive players with Mudryk.
"It's hard to find this balance but we have ambitions to win and get through a very exciting competition.
"It's very exciting for us. We need to improve our league position, we've had one final already this season and it's a great chance for us. It's not going to be easy, look at Coventry yesterday, that's why we're conscious what can happen."