Too many cancer treatment approaches turn into a game of Whac-A-Mole in which genetic resistance among cancer cells becomes amplified. To play a new, more winnable game, researchers are using genetic circuits to realize evolution-guided…
Research in mice has identified how a spreading wave of depolarization and the flow of cerebrospinal fluid to the trigeminal nerve triggers headaches, identifying a connection between aura and the migraine that follows. The findings…
Identifying a small-molecule drug that can effectively treat (or potentially cure) patients with sickle cell disease around the world is something of a Holy Grail in hematology research and drug discovery more broadly. This new work builds…
Researchers collaborated on the project to identify compounds that enhance naloxone’s (Narcan's) potency and longevity following treatment. Their team identified a compound that fits these criteria while also reducing withdrawal symptoms…
A study revealed that DNA repair mutations in the MSH3 and MSH6 genes act as a genetic switch that cancers exploit to navigate an evolutionary balancing act. On one hand, these tumors roll the dice by turning off DNA repair to escape the…
One emerging strategy to combat antibiotic resistance is the use of antimicrobial peptides. Now, a new study by researchers at the Free University of Berlin demonstrated that a common infection-bacteria Pseudomonas aeruginosa, was less…
10x formally announced the launch of Xenium Prime 5K in late May, four months after co-founder and CEO Serge Saxonov, PhD, first announced the new panel among product improvements planned for this year in January at J.P. Morgan’s 42nd…
The conserved active site of bacterial and organellar RNA splicing ribozymes has been shown to interact specifically and selectively with small molecule modulators. This work could lead to the rational design of splicing modulators not…
Researchers have shown for the first time that engineered human plasma B cells can be used to treat a disease--more specifically leukemia--in a humanized mouse model. The results mark a key step in the realization of engineered plasma…
Kisunla is the first amyloid plaque-targeting therapy with evidence to support stopping therapy when amyloid plaques are removed, which according to Lilly can reduce both the number of infusions needed as well as the treatment cost. The…
On this episode of GEN Live, we will talk about proteomics--as a tool and as a field. Where is it now and what type of research is proteomics enabling? We will also discuss the latest technologies and instruments in this space. What will…
The Autologous Cell Therapy Industrial Automation platform which complements Cellular Origins’ Constellation methodology, is focused on the autologous cell therapy manufacturing and allows for massively multiplex and distributed industrial…
For some companies, sustainability can simply mean reducing carbon footprint. Here, encouraging employees to carpool can make more impact than altering manufacturing processes. Alternatively, companies might focus on water use as a measure…
Although bioprocessing often focuses on cells, everything must stay clean--not just ordinary clean but sterilized. To explore the scope of this challenge, GEN talked with Alice Redmond, chief strategy officer at CAI, which recently…
When yeast spent media from vat fermentation is supplemented and reused, it can outperform fresh culture media, according to researchers at University College Dublin (UCD). This suggests a commercial-scale, circular green economy is…
Lentiviral vectors are used in the lab, manufacturing facility, and clinic, particularly for the production of therapies for rare disease. For example, the approved gene therapies Skysona and Zynteglo are made using lentiviral vectors as…
Absci expects 2025 to shape up into a busy year with a planned release of interim data for the lead AI-designed candidate it anticipates advancing into the clinic early next year, as well as additional preclinical development for its two…
Scientists at the Karolinska Institute have used DNA origami to develop a cancer kill switch and a nanoscale delivery vehicle, that is only activated when the structure is exposed to the acidic tumor microenvironment, thus ensuring that…
Researchers used an ATP biosensor to track ATP levels in microbial platforms. The information collected allowed the researchers to identify the preferred feedstocks for different microbes, and to reveal which steps in a synthetic pathway…
In this GEN Learning Lab, CN Bio’s CSO Tomasz Kostrzewski, PhD, and toxicology consultant Clive Roper, PhD, will discuss all things OOC, including current applications, the evolving perspective of regulators, and ongoing efforts to harness…
Spatial biology gives you the power to better understand how cells interact within tissue and how those interactions influence biological processes in healthy or diseased tissue. Thermo Fisher Scientific's high-plex fluorescent labeling…
Researchers discovered how to turn lipid-storing white fat cells into beige fat cells that burn calories, by limiting production of a protein called KLF15. Their work, primarily in engineered mice, identified the gene on which KLF15 acts,…
Enterococcus faecalis often causes hospital infections, where in many cases antibiotic therapy no longer works because the bacteria have developed resistance. These bacteria can also spread the resistance further via the type 4 secretion…
Pseudomonas aeruginosa, which is naturally found in soil and water, as well as in hospitals, nursing homes, and similar institutions for persons with weakened immune systems, is a bacteria that becomes resistant to most antibiotics in use.…
Closed systems and optimized processes can help manufacturers scale up production, drive down costs, and increase the accessibility of CAR/TCR T-cell therapies.