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21

'Practice Changing' Trial for Inoperable Locally Advanced NSCLC

(MedPage Today) -- CHICAGO -- Patients without disease progression following chemoradiotherapy for unresectable stage III non-small cell lung cancer (NSCLC) should receive osimertinib (Tagrisso) if they harbor EGFR mutations, experts said…

20

Intralesional Therapy for Melanoma Effective, May Have Systemic Activity

(MedPage Today) -- CHICAGO -- Preoperative intralesional treatment with a dual antibody-cytokine fusion significantly improved relapse-free survival (RFS) in locally advanced melanoma versus surgery alone, a randomized trial showed.

Blenrep-Based Regimen Yields PFS Benefit in Relapsed/Refractory Myeloma

(MedPage Today) -- CHICAGO -- Progression-free survival (PFS) was significantly higher with belantamab mafodotin (belamaf; Blenrep) combined with pomalidomide (Pomalyst) and dexamethasone (BPd), compared with standard-of-care pomalidomide,…

19

Virtual and In-Person Palliative Care Equally Beneficial in Advanced Lung Cancer

(MedPage Today) -- CHICAGO -- Early palliative care delivered via video was as effective as in-person visits on quality-of-life (QoL) measures among patients with advanced lung cancer, according to the REACH-PC trial.

Fast-Food Medicine: EDs Desperately Need a New Model of Care

(MedPage Today) -- Sunday, 7 a.m.: On any given Sunday morning, I expect to arrive for my emergency department (ED) shift to a department in disarray. There's a certain colliding of worlds that happens -- the wreckage of Saturday night…

16

No Survival Advantage With Sacituzumab Over Chemo in Previously Treated NSCLC

(MedPage Today) -- CHICAGO -- Treatment with single-agent sacituzumab govitecan (Trodelvy) offered no survival advantage over docetaxel in patients with advanced non-small-cell lung cancer (NSCLC) previously treated with platinum-based…

01

Subcutaneous Amivantamab Plus Lazertinib Non-Inferior to IV Dosing in NSCLC

(MedPage Today) -- CHICAGO -- Subcutaneous amivantamab (Rybrevant) was non-inferior to IV amivantamab for pre-treated patients with refractory EGFR-mutated, advanced non-small cell lung cancer (NSCLC), with the suggestion of a possible…

Saturday, Jun 1

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How Have Kids' Colorectal Cancer Rates Changed?

(MedPage Today) -- You passed medical training, now see if you can pass our weekly quiz

23

Novel Bispecific in EGFR-Mutant Lung Cancer Boosts PFS After Targeted Agents

(MedPage Today) -- CHICAGO -- An investigational bispecific antibody targeting PD-1 and VEGF significantly decreased the risk of disease progression or death in patients with metastatic EGFR-mutant non-small cell lung cancer (NSCLC) who…

21

Kinder, Gentler Regimen for Classical Hodgkin Prevails in Randomized Trial

(MedPage Today) -- CHICAGO -- Replacing chemotherapy with a targeted agent resulted in a better tolerated regimen for advanced classical Hodgkin lymphoma (cHL) with no loss in efficacy, according to a randomized study reported.

Hypertension After Kidney Donation; Statins in Old and Very Old People

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences…

19

Where Are All the Male Nurses?

(MedPage Today) -- Nurses are critical to a functioning healthcare system, yet our country is currently facing a nursing shortage that is projected to intensify in the next few years. The shortage is not just a statistic for me; it is a…

Friday, May 31

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Guillain-Barre Syndrome Rates After RSV Shots in Sync With Trial Data, CDC Says

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(MedPage Today) -- Reports of Guillain-Barré syndrome (GBS) following respiratory syncytial virus (RSV) vaccination in adults ages 60 and up were higher than expected, but the vaccine's benefits still outweigh any small potential risk,…

FDA Staff Questions Safety of MDMA Treatment for PTSD

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(MedPage Today) -- FDA staff raised concerns about the available safety data and limitations in the study design for midomafetamine (MDMA) to treat post-traumatic stress disorder (PTSD) in briefing documents released ahead of an FDA…

23

FDA Approves First mRNA RSV Vaccine

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(MedPage Today) -- The FDA approved the first-ever mRNA-1345 vaccine (mRESVIA) for respiratory syncytial virus (RSV) for people ages 60 and older to protect against lower respiratory tract disease, Moderna announced Friday in a press…

22

Woman Is Back on Dialysis After Doctors Remove Transplanted Pig Kidney

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(MedPage Today) -- A woman who received a pig kidney transplant is back on dialysis just 47 days later after surgeons removed the gradually failing organ.

21

A Single, Surprising Gene Behind a Disorder That Causes Intellectual Disability

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(MedPage Today) -- Scientists have found the genetic root of a disorder that causes intellectual disability, which they estimate affects as many as one in 20,000 young people. And they hope their discovery leads to a new diagnosis that can…

COVID Shot After Acute Coronary Syndrome Might Not Prevent Further Events

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(MedPage Today) -- Vaccination for COVID-19 after an acute coronary syndrome (ACS) event was not associated with better cardiopulmonary outcomes or fewer major adverse cardiovascular events, according to a secondary analysis of the…

The Rocky Road to Safe, Effective Rotavirus Vaccines

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(MedPage Today) -- The development of a safe, effective rotavirus vaccine was a major milestone in reducing hospitalizations and deaths from the virus in children around the globe, but the rollout of the first rotavirus vaccine did not go…

19

Hereditary Angioedema Attacks Reduced With Donidalorsen Prophylaxis

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(MedPage Today) -- An antisense oligonucleotide therapy showed efficacy as a prophylactic treatment for hereditary angioedema (HAE), the phase III OASIS-HAE trial showed.

Botulism's Most Vulnerable Victims Are Not Who You Think

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(MedPage Today) -- For several months, botulism has been making news, but not because someone bought tainted pesto from a fancy roadside stand or served bad potato salad at a church potluck. Or squirted toxic nacho cheese on chips sold at…

Tirzepatide Sheds Pounds in Chinese Adults With BMI as Low as 24

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(MedPage Today) -- Tirzepatide (Zepbound) was effective at reducing body weight in Chinese adults with lower cutoffs for overweight or obesity, the SURMOUNT-CN trial reported.

17

Fewer Suicides in Cancer Patients; Circadian Rhythm Boost; HIV Vaccine for Cancer?

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(MedPage Today) -- While suicide rates continue to rise nationwide, the rate among patients with cancer has been declining. (Translational Psychiatry)

Urologists Flee Mission Health

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(MedPage Today) -- Urologists are the latest physicians to leave Western North Carolina's Mission Health following its $1.5 billion takeover by HCA Healthcare in 2019, according to new reporting.

Fauci's Private COVID Emails Requested; Death Penalty for Abortion? WHO's Cash Woes

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HPV Testing Outperforms Pap Smear for Detecting Cervical Cancer Precursor Lesions

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(MedPage Today) -- The risk of developing cervical neoplasia 8 years after human papillomavirus (HPV) testing was similar to 3 years after a negative Pap test, a large longitudinal cohort study showed.

In RA, Poorly Controlled Pain Portends Even More Serious Problems

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(MedPage Today) -- Hospitalization and death were markedly more common among rheumatoid arthritis (RA) patients experiencing more pain and worse self-assessed health, analysis of a prospective Australian registry showed.

Quadruplet Regimens Have Become Standard for Multiple Myeloma

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(MedPage Today) -- While triplet regimens were once standard for newly diagnosed multiple myeloma, more recent studies have shown a clinical benefit of quadruplet therapy that adds an anti-CD38 monoclonal antibody for transplant-eligible…

Advances in CAR T-Cell Therapy for Multiple Myeloma

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(MedPage Today) -- B-cell maturation antigen (BCMA)-directed CAR T-cell therapies are now established options for treating multiple myeloma after relapse, but efforts are underway to expand their use and to bring novel products to the…

15

STAMP Inhibitor Tops Imatinib, Second-Gen TKIs for Newly Diagnosed CML

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(MedPage Today) -- CHICAGO -- The STAMP inhibitor asciminib (Scemblix) had a statistically superior response rate compared with investigator-selected tyrosine kinase inhibitors (TKIs) for patients with newly diagnosed chronic myeloid…